Abstract Metabolic modeling enables the study of human metabolism in healthy and in diseased conditions, e.g., the prediction of new drug targets and biomarkers for metabolic diseases.To accurately describe blood and urine metabolite dynamics, the integration of multiple metabolically active tissues is necessary.We developed a dynamic multi-tissue
Abstract Background Although genes play a key role in many complex diseases, the specific genes involved in most complex diseases remain largely unidentified.Their discovery will hinge on the identification of key sequence variants that are conclusively associated with disease.While much attention has been focused on variants in protein-coding DNA,
Summary:.Superficial vein thrombosis has traditionally been considered a disease of the lower extremity.Less frequently it can affect the breast, chest wall, penis, read more or upper extremity.Cases involving upper extremities are usually associated with intravascular access, and the vast majority remain self-limiting.This case report presents a 6